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OSTEOARTHRITIS Osteoarthritis, also called degenerative joint disease , is the most common joint disease in the world

Given the current findings, mitochondrial spheroids are considered to represent a protective alternative strategy for maintaining mitochondrial homeostasis when PINK1/Parkin-related mitophagy is hindered [169, 170]

The generation of mitochondrial NADPH by NADK2-mediated phosphorylation of NAD + is a critically important reaction that is required for mitochondrial fatty acid synthesis, mitochondrial proline synthesis, regulation of redox status, and overall systemic energy homeostasis