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Targeting the Janus face of the B2-bradykinin receptor

ChaC1 is upregulated under stress conditions such as ER stress and amino acid starvation [105], whereas ChaC2 is constitutively expressed and may act in a housekeeping fashion [5]

Rectal glutathione delivery eliminates digestive tract and liver metabolism losses, providing 40-50% more bioavailability through rectal vasculature

As a potential cancer treatment, it has also been observed that the effects of VIC on cancer are dependent on the route of administration, whether oral or intravenous, as well as on the mode of transport of VIC into tumoral cells (Figure 4)

Obtained images were measured using ImageJ software (National Institutes of Health, Bethesda, MD, USA)

Among its oxidation products there are the 8-hydroxy-2-deoxyguanosine (8-OHdG) and the 8-oxo-7,8-dihydroguanine (8-oxoGua) (Zhang et al., 2013)