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Ren Fail 44(1):862880 Shao K, Guan F, Dong C (2021) Efficacy and mechanism of the adjuvant treatment of purpura nephritis in children with total white peony glycosides: a prospective randomized controlled study

Excretion Pathways Limited data on excretion mechanisms indicates: Probable renal elimination of peptide fragments Potential hepatic clearance contribution No comprehensive mass balance studies in peer-reviewed literature Excretion kinetics require systematic investigation The disconnect between presumed rapid clearance and prolonged metabolic effects represents a critical knowledge gap requiring mechanistic clarification through rigorous pharmacokinetic studies

Collectively, by disrupting fibroblast proliferation, migration, and differentiation into myofibroblasts, nintedanib blocks fibrosis progression (Liu et al., 2022a

However, whether plant-type Fds act as an in vivo recipient protein for NEET-type 2Fe-2S from AT-NEET is still questionable, because plant-type Fds are known as classic 2Fe-2S proteins