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And many of the things that people are well aware of, higher levels of blood sugar, for example, infections can do it, inflammatory chemicals in the body, i.e., inflammation from anywhere in the body, i.e., leaky gut can relate back to the brain and change these important cells that make up about 10 to 15% of the brain cells that are involved in maintenance that can change these cells from being friend to foe

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in those cases protein-binding displacement can result in a large rise in the amount of unbound drug available to the target tissue