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Description
May 30 2020;21(11)doi:10.3390/ijms21113943

Symptoms are often vague and easy to attribute to aging, stress, or overtraining

Paradoxine (a special grains of paradise extract) stimulates brown fat thermogenesis which also ramps up energy expenditure

ruthenicum in the therapeutic treatment of EIF should be further investigated, ultimately identifying the main anti-fatigue substances, which could be further refined in both commercial and clinical applications in the treatment of fatigue

The annual costs arising from the resulting human health losses in 2010 were about 90 million (FCC Consortium, 2010)

Its main mechanism of action is not yet fully understood, although its effects on fatigue seem to be related to its dopaminergic effects, supporting the dopamine imbalance theory for MS-related fatigue
