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G6PD def is an X-linked genetic disorder present in 300-400 million people worldwide [2]
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Concurrently, persistent elevation of fibroblast growth FGF23 not only downregulates CYP27B1 but also induces the catabolic enzyme CYP24A1, accelerating the degradation of active vitamin D and further impairing its biological activity (13)

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10.1038/s41386-019-0411-y 28 RourkeE.LawF

Gastric acid frees elemental iron from heme and nonheme products
