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A static representation of the topology and electrostatic field in the H-site (Warshel, 1998) will have to be complemented with a description of the dynamics of the entire molecule ( Substrate Discrimination in Promiscuous Enzymes GSTs, like many other enzymes involved in detoxication, are promiscuous such that they can act on several different substrates and catalyze many alternative chemical reactions

The Bcl-2/Bax ratio increased and cleaved caspase-3 levels dropped, indicating reduced apoptosis (Pyo et al., 2007)

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Meanwhile, CIH may affect cytokine levels in the TME, such as tumor necrosis factor- (TNF-), interleukin-8 (IL-8), and interleukin-6 (IL-6), through the activation of NF-B (Li et al., 2011)

Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement

when exposed to tumor-associated enzymes or acidic pH cleavable linkers are known to those of skill in the art