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Cholesterol is embedded in membranes, and, therefore, sensing changes in sterol levels occurs in membranes by two proteins embedded in endoplasmic reticulum membranes that contain sterol-sensing domains, HMG-CoA and SREBP cleavage-activating protein (SCAP)

[DOI] [PubMed] [Google Scholar] 293.Poulos A., Sharp P., Johnson D., Easton C

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It was early in the morning of such a day as the poet refers to that we commenced a ride and a ramble over the historic grounds of Saratoga near Schuylerville, accompanied by the friendly guide whose proffered services I have already mentioned