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Unlike typical cellular proteins, MOTS-c is encoded in the mitochondrial genome but translated in the cell cytoplasm, highlighting the unique cross-talk between mitochondria and the rest of the cell

The model is also consistent with published results that show that female mice are less susceptible than males to hepatotoxicity due to acetaminophen overdose and suggests that this might also be true for humans, though the human epidemiological data are contradictory.

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