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Consequently, MRD is particularly common with rapamycin treatment, meaning that lifelong therapy is required, with consequent long-term toxicity, including stomatitis, rash, and fatigue (46, 47)

These markers are used in diagnostic assessments to evaluate the extent of oxidative damage and to guide antioxidant therapy aimed at reducing lipid peroxidation and improving sperm function

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doi: 10.1016/S0002-9440(10)63645-0
doi: 10.3390/jcm14134492