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Integrated Systems Physiology: from Molecule to Function to Disease

CARE: Secondary End Points Reductions observed in: % P Confirmed nonfatal MI 23 0.02 MI, fatal and nonfatal 25 0.006 CABG 26 0.005 PTCA 23 0.01 Sacks FM et al

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Plasma levels of TMAO are suppressed when individuals take antibiotics A short-term crossover feeding trial in healthy young men showed that TMAO production is a function of individual differences in the gut microbiome, and demonstrated differences in how microbiota respond to dietary TMAO and its precursors (Cho et al

Journal of Biological Chemistry, 2015

Its also important to separate support from treatment. Supplements can be part of a thoughtful routine, but they dont replace diagnostics, prescription diets, or medical management