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These three NIS inhibitors can be present in drinking water, however not exceeding usually safe concentrations, as it has recently been confirmed for example in different districts in Antalya (Turkey) [32]

Up-regulation of GPX4 was proven to depress ferroptosis in IS or HS, while excessive and lethal accumulation of lipid ROS in biofilms led to the depletion of GSH and inactivation of GPX4 (Jin et al

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