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Another advance was the cloning of the intercellular proteins such as zonulins, claudins, occludins, tricellulins, and the many other protein components that comprise the tight junctions, facilitating the understanding of their contributions toward junctional structure and paracellular permeability [33, 38]

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When used together, they are thought to intensify each others' effects and are usually injected together as part of the same treatment injection cycle

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