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Retrieved December 19, 2023

By competitively binding FOXO4, it prevents FOXO4 from sequestering p53, thereby restoring the cells intrinsic apoptotic signaling capacity

We think that the [neurons influence] on intervertebral disc degeneration is not only limited to the occurrence of pain, but also intervertebral disc degeneration itself, said Ximing Xu, professor in the Department of Orthopedic Surgery in Changzheng Hospital, and co-lead author of the study