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Although IFN- augments the anti-tumor efficacy of CD8 + T cells, the tumor immune microenvironment (TIME) considerably affects this mechanism, possibly restricting ferroptosis in immunologically inert malignancies (57, 58)

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Auger, S., Yuen, W., Danchin, A

In the absence of the UROgenIII-Cosyn, the symmetrical linear tetrapyrrole spontaneously closes into a symmetrical porphyrin ring of the type I configuration
