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For decades, these cells were viewed primarily through the lens of neuroinflammation and neuronal damage, particularly due to their well-documented release of pro-inflammatory cytokines, including TNF-, IL-1, and IL-6 in conditions like AD and PD [124, 453455]

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These combined experiments, uncover some distinctive features between the GDF11 and GDF8 mature domains in vivo , suggesting that the endogenous mature ligands are functionally different

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