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Many investigations have shown that crude black seed or its active components have various biological activities, including anti-cancer, anti-oxytocic, anti-tussive, anti-pain, antipyretic, analgesic, and antioxidant activities []

ROS stabilize HIF1 and activate NRF2, and their aberrant activation can facilitate adaptations to hypoxia, stimulate angiogenesis, and enhance cell proliferation (Chandel et al., 2000

Oncogene 25 , 63616372 (2006)

By targeting key pathwaysincluding gut microbiota homeostasis, HPA axis function, neuroinflammation, and brain plasticityVNS demonstrates potential to mitigate PD progression across multiple systems

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Quercetin prevents small intestinal damage and enhances intestinal recovery during methotrexate-induced intestinal mucositis of rats