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His96 inserts into a deep hydrophobic pocket lined by RBD residues Ala351, Tyr352, Arg466 and Ile468, and buries 105.7 2 of the surface area (Fig

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Besides, it markedly diminished gene expression of inducible nitric oxide synthase (iNOS) assessed by real time PCR technique, as well as protein levels of IL-1, IKK, NF-B, NLRP3 and galectin 3 emphasizing its potent anti-inflammatory effects