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In 2014, Mayes et al
PMC 9207324
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Evaluations should be conducted across various clinical trial phases-including Phase I, Phase II, Phase IIb, and Phase III-to tailor antioxidant therapies to specific disease subtypes, ranging from simple antioxidant interventions to combination therapies

This hypothesis is backed by studies showing that the analgesic effects of acetaminophen are partially reversed by drugs that deplete serotonin levels