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Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases

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Increased levels of reactive oxygen species (ROS), such as superoxide anion, and involvement of its main producer, the NADPH oxidase (NOX) enzyme, have been demonstrated in CF mice models and human cell lines (Esposito et al., 1999

Interestingly, PC is like GS an astrocytic enzyme (45, 46) and accordingly de novo synthesis of the carbon skeleton of glutamate and GABA via glutamine requires astrocytic participation [see Ref