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Research has investigated the mechanisms by which NNMT inhibition might increase energy expenditure, potentially through effects on mitochondrial function or uncoupling protein expression

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Additional information Competing interests Authors have nothing to disclose

Preventive : a dose every one or two weeks

The concentration and quality of extracted DNA were determined using a Multimode Microplate Reader (PHERAstar FSX, BMG LABTECH, Germany)

Navitoclax (ABT-263), another inhibitor of the BCL-2 family members, has also been used in many different studies over the years for its ability to eliminate senescent cells by inducing apoptosis