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We systematically estimate the trend and the seasonality using time series modeling techniques such as additive decomposition, Holt-Winters exponential smoothing and locally weighted regression models with seasonal covariates

However, observational studies suggest that whilst acute toxicity remains exceptionally rare, sustained very high levels of B12particularly from supplements or injectionsmay be associated with certain health concerns, though these are correlations rather than proven causal relationships

Its also known to cause other unpleasant side effects, from body odor to diarrhea

doi: 10.1371/journal.pone.0231870 65

The Nrf2/KEAP1 signaling pathway serves a key role in maintaining redox homeostasis

Three experimental glaucoma models in rats: Comparison of the effects of intraocular pressure elevation on retinal ganglion cell size and death