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J Mater Chem B 4:52175221

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However, excessive NRF2 signaling suppresses expression of critical microbicidal effector molecules in bone marrow-derived macrophages (BMMs), impairing mycobacterial clearance ( To determine whether Rv0801 influences the KEAP1-NRF2 axis, we first analyzed Nrf2 transcriptional activity in THP-1 macrophages infected with Rv0801 recombinant strains

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Similarly, knocking out the transporter in zebrafish, Danio rerio , results in increased oxidation of DNA, as revealed by accumulation of 8-oxoguanine (104)

[DOI] [PMC free article] [PubMed] [Google Scholar] 114.Cabreiro F., Au C., Leung K.Y., Vergara-Irigaray N., Cochem H.M., Noori T., Weinkove D., Schuster E., Greene N.D., Gems D