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Alternatively, -ketoglutaric acid in succinyl-coenzyme A can be oxidized indirectly through mitochondria dehydrogenase to generate NADH, which is responsible for ROS overproduction ( Role of Oxygen in Mitochondrial Function Oxygen is key to the functionality of mitochondria

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After being stimulated by fibrogenic factors, HSCs change from vitamin A-storing latent cells to active cells that resemble myofibroblasts, depositing an abundance of ECM, especially type I collagen

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