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241 These oxidants can further impact a variety of signaling pathways associated with pathological processes, resulting in BBB dysfunction eventually

They act as coenzymes in mitochondrial energy metabolism by supporting enzymes in the Krebs cycle and in the electron transport chain, thus indirectly preventing excessive ROS formation, as they are not direct antioxidants because they do not chemically neutralise free radicals

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The three deiodinases shared about 50% sequence similarity, and share a common function: DIO1 and DIO2 activate thyroid hormones T 3 and T 4 , while DIO3 inactivates them (Bianco and da Conceicao, 2018)

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Evidence Boundary Included here only to clarify the evidence gap
