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The extracellular matrix (ECM), traditionally considered a passive scaffold, is now recognised as an active metastasis promoter in target organs, making it a focus of recent studies (Figure 5), (Henke et al., 2020

Grywalska E, Pasiarski M, Sosnowska-Pasiarska B, Macek P, Roliska A, Samardakiewicz M, et al

www.cdc.gov/lyme/stats/humancases.html

Exploiting gelatin nanocarriers in the pulmonary delivery of methotrexate for lung cancer therapy

According to reports, curcumin is a P450 inhibitor that inhibits CYP2C9, CYP1A2, CYP2D6, CYP2B6 and CYP3A4, with particularly low IC50 values for CYP2C9 (Appiah-Opong et al., 2007)