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c-Met activation could exacerbate this

Similarly, oxaliplatin prompts the senescence in the same mechanism as cisplatin, of cancer cells extracted from rats with sizable tumors in the colon [45, 77]

The most common adverse effects from the SURMOUNT trials include: Nausea: 24-33% of participants (dose-dependent) Diarrhea: 18-25% of participants Constipation: 13-17% of participants Vomiting: 8-12% of participants Decreased appetite: 10-15% of participants Most of these effects are mild to moderate and occur primarily during dose escalation periods

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