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Gut Microbiota Signature in Heart Failure Defined from Profiling of 2 Independent Cohorts

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Rae CD, Williams SR

Access this article Similar content being viewed by others Abbreviations Drp1: dynamin-related protein 1 GFP: green fluorescent protein ROS: reactive oxygen species OXPHOS: oxidative phosphorylation NMDA: N -methyl-d-aspartate MD: middle domain GED: GTPase effector domain VD: variable domain SUMO: small ubiquitin-like modifier S: serine DNM1L: dynamin-1-like protein CCI: chronic constrictive injury ddC: 2,3-dideoxycytidine DRG: dorsal root ganglia Mff: mitochondria fission factor Fis1: fission protein 1 PKA: protein kinase A Ref-1: redox-factor 1 NOX4: type 4 isoform O-GlcNAcylation: O-linked - N -acetylglucosaminylation CDK1: cyclin-dependent kinase 1 NOS: nitric oxide synthase mPTP: mitochondrial permeability transition pore SOD: superoxide dismutase GSH: glutathione Mdivi-1: mitochondrial division inhibitor ODN: oligodeoxynucleotide HBO: hyperbaric oxygen pAMPK: phosphorylated AMP activated protein kinase CaMKK: calmodulin-dependent protein kinase kinase BHB: -hydroxybutyrate KD: ketogenic diet References Amiri M, Hollenbeck PJ (2008) Mitochondrial biogenesis in the axons of vertebrate peripheral neurons

To test the feasibility of using Cys and its oxidized species as a measure of oxidative stress, we developed a high-throughput quantitative assay for the simultaneous analysis of a panel of small-molecule thiols and disulfides by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) using multiple reaction monitoring (MRM) coupled with stable isotope dilution

When the valves inside the veins fail to function properly, blood flows