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Additionally, curcumin exhibits significant anti-inflammatory properties by downregulating microglial activation, reducing proinflammatory cytokines, and attenuating TLR4/MyD88/NF-B signaling cascade after TBI (Xie et al., 2014

An unopened vial left out overnight faces lower risk than a reconstituted vial in the same conditions

As the key enzyme metabolizing APAP into NAPQI, cytochrome P450 enzymes are also considered to be intriguing target for the treatment of APAP-induced liver injury

With a needle placement procedure performed by clinicians, paVNS is ideal for acute clinical settings (e.g., postoperative pain control) and patients who struggle with selfstimulation adherence (Ilfeld et al

Funding This work was funded by the So Paulo Research Foundation, FAPESP, grants 2022/14645-2 (to M.G.O.), 2025/00254-0 (to D.M.G), 2024/08075-4 (to E.A.P.J.) and, 2023/17022-9 and 2018/26080-4 (to A.P.D.)

doi: 10.3390/ijms23158446 51 SatoKMiyamotoMTakanoMFuruyaKTsudaH