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Interestingly, a specific GPX1 polymorphism resulting in a proline-to-leucine transition at position 198 (Pro198Leu) is associated with a reduction in GPx1 activity and found to be more prevalent in Keshan patients

doi: 10.1158/0008-5472.CAN-10-2274

N-Acetyl-L-Cysteine Benefits: Promotes healthy cellular glutathione levels Provides powerful antioxidant support Supports immune system health Encourages liver health & function Promotes bronchial & respiratory health Suggested Use: Take one (1) capsule one to three times daily, or as recommended by a healthcare practitioner

PMID 24574100

Nutrition Reviews , 70(3), pp
It all depends on various things like weight, skin type, tone, etc
