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ROS formed during physiological reactions are necessary for proper gene expression and cell differentiation but in excess, ROS lead to the formation of DNA lesions and can impact the integrity of the nuclear and mitochondrial DNA (mtDNA)

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intramuscular route: count injections given Visit 4 (week 52) Anamnesis: record lifestyle habits and use of alcohol Symptoms: record paresthesia, asthenia, loss or reduction of appetite, sadness or change in level of happiness, and concomitant pharmacological treatment Physical examination: for Hunters glositis, positional and vibrational sensitivity Record concomitant treatment Questionnaires: EuroQoL-5D, satisfaction and preferences Assessment of haemogram and serum vitamin B12 concentration Assessment of adverse effects Assess adherence to treatment: oral route count number of vials used

Thus, our findings are not surprising but suggest that future studies investigating IL-8 signaling could improve the understanding of sarcoidosis pathogenesis and potentially phenotypes