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Several protein kinases such as protein kinase B (Akt), extracellular signal-regulated kinase (ERK), p38 mitogen-activated protein kinases (p38MAPK), and c-Jun N-terminal kinase (JNK) phosphorylate FoxO transcription factors in response to elevated levels of ROS and upon exposure of cells to stressful stimuli [143]

Neuron 101, 459471.e5

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[DOI] [PubMed] [Google Scholar] 135.Shimada K, Skouta R, Kaplan A, Yang WS, Hayano M, Dixon SJ, Brown LM, Valenzuela CA, Wolpaw AJ, Stockwell BR

Identifies induction of pluripotency genes [Sox2, Oct4 (Pou5f1), Nanog] as a mechanism by which hypertrophic chondrocytes transdifferentiate into bone-forming osteoblasts during endochondral ossification

Premature agingthink fine lines, uneven skin tone, loss of firmnessoften begins when collagen and elastin are degraded faster than the body can replenish them