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However, it has also been observed that hormone-induced phosphorylation of serine 10 in H3 histone (H3S10) prevents the rapid remethylation of the preceding lysine, serving as the metronome of the process and giving the DNA damage repair system enough time to eliminate the oxidized nucleotides from nearby DNA 143

Given that deep sleep is when the body does most of its repair and growth hormone secretion, DSIP has relevance extending well beyond sleep research

[DOI] [PubMed] [Google Scholar] Stanasila L, Abuin L, Dey J, Cotecchia S

Cell Death Dis, 2016

Pure Difference: What we leave out matters, too

They do not have any significant side effects