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[75] verified that adult human NSCs can significantly reduce tissue and neural function loss, which is mediated through its paracrine neuroprotective and proangiogenic activities through the Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) signaling pathway

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doi: 10.1016/j.reactfunctpolym.2013.04.011

The design principle: Standard (often fails): His6 - TEV site - Target protein Better: His6 - TEV site - (GGS)2 - Target protein Even better: His6 - (GGS)2 - TEV site - (GGS)2 - Target protein Failure 2: Non-Specific Cleavage (The Protease Damages Your Protein) The problem: Proteases aren't perfectly specific

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Novel solid self-Nanoemulsifying drug delivery system (S-SNEDDS) for oral delivery of olmesartan medoxomil: design, formulation, pharmacokinetic and bioavailability evaluation
