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The GluN2 subunits have differential expression and distribution in specific brain regions, neuronal types, and locations

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Biological Psychiatry, 77 (6), 526536

Paradoxically, while normal prostate physiology prioritizes polyamine synthesis (e.g., spermine), regulated by androgen-dependent enzymes like ODC to support secretory functions, PCa progression exhibits a contradictory polyamine landscape: spermine levels decline sharply despite ODC overexpression, a phenomenon contrasting with polyamine accumulation patterns in other cancers

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While NAD supports energy production and cellular repair, NAC enhances antioxidant defenses