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[12] Similarly to most other metabolites and anions, the transport of pyruvate across the outer mitochondrial membrane is probably mediated by a relatively nonspecific, voltage-dependent anion channel

[DOI] [PMC free article] [PubMed] [Google Scholar] 52.Brkle A., Moreno-Villanueva M., Bernhard J., Blasco M., Zondag G., Hoeijmakers J.H.J., Toussaint O., Grubeck-Loebenstein B., Mocchegiani E., Collino S., et al

doi: 10.1016/s0306-3623(97)00418-7
This measures the amount of B12 that is available for the cells to absorb and use

Therefore, more randomized controlled trials are required in this regard