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Description
Proteomic analysis showed that these significantly differentially expressed proteins are involved primarily in metabolic pathways including carbon metabolism, amino acid biosynthesis, pyruvate metabolism, glucagon signaling, pentose phosphate pathway, HIF-1 signaling and glycolysis/gluconeogenesis (Figure 4C)

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This may be due to lack of production of a hormone by the kidneys (erythropoietin or EPO) that stimulates production of red blood cells in the bone marrow, but can also be due to other factors (such as loss of blood in the intestines)

In addition, FOXO4 inhibition in cells that were already senescent, but not their control counterparts, reduced viability and cell density (Fig

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