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Class II FINs (e.g., RSL3) can directly inhibit GPX4 and reduce its activity

GAS is the principal etiologic agent of both rheumatic fever and rheumatic heart disease, the two major postinfectious complications responsible for a large proportion of the over 320,000 GAS-related deaths reported annually 13
p = 0.279) as well as at 45 days of VLCKD active phase (control group: 1.8 2.3 mg/L, VLCKD + MCTs: 1.5 1.8 mg/L, VLCKD + earlyMCTs: 1.4 1.7 mg/L

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The exact mechanism of why and how this happens is not well investigated yet