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NNMT becomes a metabolic problem when it is overexpressed which is precisely what happens in obesity

doi: 10.1016/S0014-5793(97)01424-5

Discovery of a lysophospholipid acyltransferase family essential for membrane asymmetry and diversity

This can degrade the compounds, reducing their potency and potentially rendering your research data invalid
Renal tubular effects of prolonged therapy with the GLP-1 receptor agonist lixisenatide in patients with type 2 diabetes mellitus

The spectrum of inflammatory responses