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Comparing only headline percentages: REDEFINE 1 and REDEFINE 4 answer different questions

Nevertheless, we hereby present a key mechanism hypothesis that awaits validation

This inconsistency in efficacy assessment may stem from differences in disease stage, statin type, and treatment timing, highlighting the uncertainty regarding its clinical benefits

Dosing frequency in research protocols reflects the dihexa half life directly

The AT mechanism of all of the above-mentioned compounds usually involves conversion of manganese to an Mn IV -oxo form, which is then reducible by endogenous or exogenous AT (e.g., glutathione or vitamin C) activity (Halliwell and Gutteridge, 2015)