oxidative stress parameters glutathione Changes in related parameters: (a) Reduced Role of oxidative stress in

For example, studies using rodents and primary neuron cultures have demonstrated that sulforaphane upregulates key antioxidant enzymes, such as glutathione-S-transferase (GST), NAD(P)H oxidoreductase 1 (NQO1), and heme oxygenase-1 (HO-1), leading to reduced oxidative burden in both neurodevelopmental and neurodegenerative models (Innamorato et al., 2008

Kazazica and co-workers (2006) demonstrated that flavonoids, such as kaempferol, chelated Cu 2+ and Fe 2+ through the functional carbonyl groups

Clin Nucl Med 4:181190 Elte JW, Bussemaker JK, Haak A (1990) The natural history of euthyroid multinodular goitre

Kauser S

NRF2 affects multiple aspects of metabolism and mitochondrial function, from nutrients uptake, anabolic metabolism, macromolecular biosynthesis to energy metabolism that support cell growth and proliferation [76]

Depression not only may promote cognitive impairment, but also may be a risk factor for AD [14]