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Psychiatric disorders, including schizophrenia, and mood disorders, such as major depressive disorder (MDD) and bipolar disorder (BD), have been linked to dysregulation in the cholinergic system and dysfunction of cholinergic muscarinic receptors, specifically the M 1 and M 4 receptor for schizophrenia and the M 2 receptor for BD [510]

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Davies, S

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Learning Objectives By the end of the self study you should be able to: Define the concepts of loading dose, bioavailability, volume of distribution (Vd), clearance & elimination half-life

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The consequences extend beyond simple fatigue: B12 deficiency can trigger mood disturbances, cognitive decline, nerve damage, and compromised immune function

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I cried, said Wendy L., a long-term migraine sufferer

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