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A key feature is ECM degradation, which results from the upregulation of MMPs and ADAMTSs, leading to the breakdown of proteoglycans and collagen, ultimately causing structural damage to the intervertebral disc (36,37)

Subcutaneous injections can be administered at the side or back of the upper arm, lower abdomen, and front of the thigh

Chloroquine and doxycycline were obtained from SigmaAldrich (Saint-Louis, MO)

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PGC1 downregulation and glycolytic phenotype in thyroid cancer

Group A RBD mAbs (WRAIR-5005, -5020, -5021) completely blocked hACE2 binding to both RBD and the stabilized Spike trimer S-2P, whereas Group B RBD mAbs (WRAIR-5001, -5004, -5011) had incomplete hACE2 blocking activity against both RBD and the Spike trimer S-2P (Fig