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Overexpression of AKR1B1 can lead to excessive generation of PGF2 and COX2 resulting in inflammation and tumor development [135,136]
It has been reported that oxidation and other cumulative age-related changes cause a gradual decrease in the fluidity of the membrane, and the constant rigidity of the cytoskeleton makes senesced RBCs firm (21)

Bhat TA, Panzica L, Kalathil SG, Thanavala Y

mTORC1 and mTORC2 selectively regulate CD8 + T cell differentiation

Two of these pathways involve the addition of highly water-soluble structures: glucuronate via the glucuronide pathway or sulfate via the sulfation pathway

References 1 Torres-TijiYFieldsFJMayfieldSP
