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compared with baseline, cyclosporine A blood concentrations decreased by 30 % when patients were supplemented with 1000 mg vitamin C and 800 IU vitamin E (T) per d ( Reference Lake, Aaronson and Gorman 91 )

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doi: 10.1016/j.bbadis.2018.10.010

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In this mini review, we highlight and update the work by Dr Ames and colleagues since the proposal of the Triage Theory, with focus on the role of zinc in maintaining cellular antioxidant defense and DNA integrity