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Seven days of L-citrulline supplementation at a daily dose of 2.4 g was shown to significantly increase plasma nitrite and nitrate, citrulline, and arginine

Long-term effects of repeated cycles have not been mapped in published Western trials

Concomitant therapies must be checked for eventual drug interactions with the supplement, affecting medication efficacy, or causing adverse effects, requiring healthcare provider guidance for safe integration, especially with neurologic conditions, to prevent negative outcomes and ensure optimal patient care

you can mix them into the same drinks

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however, preclinical and formulation research guide absorption, stability, and safe ranges