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These diverse applications require extensive additional research to establish safety and efficacy profiles appropriate for clinical translation, but suggest GHK-Cu's therapeutic potential may extend substantially beyond current dermatological applications, potentially overlapping with emerging applications of other regenerative peptides including cerebrolysin for neurological applications and peptides targeting musculoskeletal regeneration

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In a study with senescence-accelerated mice and normal aging controls, treatment with SF for about a year significantly improved long-term memory and increased hippocampal mRNA and protein levels of peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC1) and mitochondrial transcription factor A (TFAM), both of which are master regulators of mitochondrial biogenesis