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Ionophores are a special type of antibiotic that selects certain types of rumen bacteria that help with improving feed efficiency, particularly in finishing cattle

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Under unfolded protein stress conditions, GRP78 binds to unfolded or misfolded proteins and subsequently activates downstream ER stress sensors, including IRE1, PERK, and ATF6, to trigger a response to unfolded proteins (Yoboue et al., 2017) , (Wei et al., 2012)

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