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Moreover, compared with WT serum-treated group, GCGR-KO serum-treated islets showed increased glucagon secretion under both normal (7 mM glucose) and low glucose (1 mM glucose) conditions (Fig
While current redox proteomics in CF often focuses on identifying which proteins are modified (e.g., carbonylated, glutathionylated), techniques like FPOP offer the potential to delve deeper into how these modifications occur - identifying specific residues targeted by ROS - and how these modifications, or the oxidative environment itself, impact protein structure, dynamics, and interactions (Johnson et al., 2019
10.1556/APhysiol.101.2014.007 70
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2c,d), thus arguing against the involvement of these parameters in the differential regulation of BHB production
