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In normal oxygen conditions, HIF-1 is continuously produced but rapidly degraded by the proteasome via prolyl hydroxylases (PHDs), enzymes that require oxygen

In the early subclinical phase, dogs do not show any outward signs of DCM but ECGs (electrocardiogram) can detect arrhythmia and abnormal heart sounds

renal impairment can further exacerbate neuropathic symptoms through the accumulation of uremic toxins that adversely affect nerve function
Abstract Maple syrup urine disease (MSUD) is a genetic disorder of the metabolism of branched-chain amino acids (BCAAs)

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